Emission Color Manipulation in Transparent Nanocrystals‐in‐Glass Composites Fabricated by Solution‐Combustion Process. Nomogram to predict postpartum hemorrhage in cesarean delivery for women with scarred uterus: A retrospective cohort study in China. Uterine fibroids are common benign neoplasms, with a higher prevalence in older women and in those of African descent. Considering the influence of black race on UF risk,7, 27, 43, 44, 95 the underrepresentation of African women in the available data may have introduced some bias into the analysis of UF occurrence and risk factors. and you may need to create a new Wiley Online Library account. Data on the incidence of UFs reported in four large US registry studies (N, 9910–1 795 473; median, 42 098) ranged widely, from 217 cases per 100 000 women‐years in the California Teachers Study to 3745 cases per 100 000 women‐years in the Black Women's Health Study (Figure 1A).44, 48-70 The incidence reported from the Black Women's Health Study, in which all participants were black, was consistently higher than that in the California Teachers Study and the Nurses’ Health Study II (845–1348 cases per 100 000 women‐years), in which 3% and 1% of participants were black, respectively.44, 48-70 In the Nurses’ Health Study II, the incidence of UFs among Hispanic, Asian and white women was similar, but the incidence in black women was approximately three times higher than in the other populations (Figure 1B).44 This pattern was unchanged by the method of diagnosis of UF. Over half the studies relied on self‐report and may therefore have been affected by recall bias. Any queries (other than missing content) should be directed to the corresponding author for the article. In addition, we have assessed the importance of the numerous risk factors that have been associated with the condition to identify the key factors that influence its occurrence. Lee SR, Lee ES, Lee YJ, Lee SW, Park JY, Kim DY, Kim SH, Kim YM, Suh DS, Kim YT. Developing risk models for multicenter data using standard logistic regression produced suboptimal predictions: A simulation study. Risk factors. Data on UF incidence, prevalence and associated risk factors were extracted from 60 publications. Risk Factors: Incidence rates are found to be two-to-three fold greater in African American women, compared to Caucasian woman 1,3. Over 30 factors relating to demographic characteristics, reproductive and disease status, dietary and other environmental conditions were found to have a significant effect on UF risk (Table S2). Objectives: We assessed the study and reporting quality of each study using the STROBE checklist,45 and also evaluated the risk of recall, selection and detection bias in each study. Mass spectrometry imaging: An emerging technology for the analysis of metabolites in insects. Black race was the only factor that was recurrently reported to increase UF risk, by two–threefold compared with white race. For each study, we extracted data on: study period; study type (e.g. Uterine fibroids occur in about 70% of women. In the Cancer and Steroid Hormone Study, smoking was associated with one third the risk of UFs in women with a BMI ≤22.2 kg/m2 compared with women with similar BMI who had never smoked (Figure 3B; Table 1).75 Smoking did not alter UF risk in women with a BMI greater than the median in this study (>22.2 kg/m2; Figure 3B). In addition, we have evaluated the relative strengths of over 30 factors reported to have a significant effect on UF risk and identified black race as the only factor consistently reported to increase UF risk, and 11 other factors that affect it to a similar or greater magnitude. Most studies on UF epidemiology published before the mid‐1990s were based on diagnosis by pathological examination of surgical specimens.30 These older data therefore represent a population of highly selected patients who required hysterectomy, who may constitute only 10–30% of women with ultrasound evidence of UFs.43, 44 The development and widespread use of ultrasonography for UF detection since the mid‐1990s has expanded the epidemiological data on UFs to represent a wider population. Please check your email for instructions on resetting your password. Development and Validation of Hormonal Impact of a Mouse Xenograft Model for Human Uterine Leiomyoma. Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women. Journal of Obstetrics and Gynaecology Research. Complementary Therapies in Clinical Practice. In a retrospective, single‐centre study of the ultrasound records of women in Israel experiencing UF symptoms, those aged 41–50 or 51–60 years were 10 times more likely to have UFs than those aged 21–30 years (Table 1).74 However, in a postmenopausal age group, i.e. USA.gov. Learn about our remote access options, Division of Reproductive Endocrinology and Infertility, Departments of Obstetrics and Gynecology and Surgery, Mayo Clinic, Rochester, MN, USA. Narasimman M, De Bedout V, Castillo DE, Miteva MI. Analyses of the Nurses’ Health Study II and the Black Women's Health Study showed that inclusion of pelvic examination as a diagnostic method in addition to ultrasound or hysterectomy can increase the reporting of UFs compared with ultrasound or hysterectomy alone (Figure 1A).44, 62. COVID-19 is an emerging, rapidly evolving situation. However, a large proportion of fibroids remain undiagnosed since most are asymptomatic. Over half the studies (60%; 36/60) relied on self‐report and may therefore have been subject to recall bias. Wide ranges were reported in both UF incidence (217-3745 cases per 100 000 women-years) and prevalence (4.5-68.6%), depending on study populations and diagnostic methods. Owing to the large number of risk factors discussed in the selected studies, here we focus on those risk factors for which the magnitude of the effect was approximately the same as or greater than the effect of race (Table 1; i.e. Publications reporting relevant data from registries and other observational studies with over 1000 patients and single-centre studies with over 100 patients were selected. Uterine fibroids: from observational epidemiology to clinical management. Journal of Assisted Reproduction and Genetics. To examine UF epidemiology and to evaluate the relative strengths of putative risk factors. Elagolix for Heavy Menstrual Bleeding in Women with Uterine Fibroids. Learn more. European Journal of Obstetrics & Gynecology and Reproductive Biology. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Journal of Minimally Invasive Gynecology. © 2017 IPAS. 2 Fibroids are benign smooth muscle tumors of clonal origin. The UF risk factor with the strongest evidence is black race. This disease has a profound impact on health care delivery and costs worldwide. Please enable it to take advantage of the complete set of features! international or local populations with different racial compositions, women undergoing screening or treatment, or survey respondents), diagnostic methods used (e.g. Metformin use is associated with a lower risk of uterine leiomyoma in female type 2 diabetes patients. NLM Laparoscopic management of a degenerating cystic leiomyoma imitating an ovarian cyst: A case report. Management of Cesarean Myomectomy in a Patient with Multiple Fibroids and an Obstructing Lower Uterine Segment Fibroid. Dependent. Package inserts of oral contraceptives in Italy, Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound‐screening study, Hair relaxer use and risk of uterine leiomyomata in African‐American women, Cervical neoplasia‐related factors and decreased prevalence of uterine fibroids among a cohort of African American women, Heritability and risk factors of uterine fibroids – the Finnish Twin Cohort study, The burden of uterine fibroids in five European countries, Prevalence of self‐reported medical diagnosis of uterine leiomyomas in a Brazilian population: demographic and socioeconomic patterns in the pro‐saude study, Uterine fibroids: a ten‐year clinical review in Ilorin, Nigeria, Management of uterine fibroids in Enugu, Nigeria, Myomectomy at the Federal Medical Centre Gombe, Uterine leiomyoma at the surgical department of the Teaching Hospital of Dakar, Report of 140 cases operated in two years, The relationship between thyroid nodules and uterine fibroids, Association of intakes of fat, dietary fibre, soya isoflavones and alcohol with uterine fibroids in Japanese women, Population‐based case‐control study on risk factors of uterine myomas, Incidence and characteristics of uterine leiomyomas with FDG uptake, Self‐report versus ultrasound measurement of uterine fibroid status, Association of hypertension, hyperglycemia, hyperlipemia with the risk of uterine leiomyomata for female staffs in railway system, Epidemiological data for uterine fibroids in France in 2010‐2012 in medical center – analysis from the French DRG‐based information system (PMSI). Leiomyomas in an African Caribbean hysterectomy population considered to be ethnically related to African Americans. Contemporary treatment utilization among women diagnosed with symptomatic uterine fibroids in the United States. CONCLUSION: We found a decreasing trend of new uterine fibroid diagnoses among predominantly symptomatic women ages 18-65 years in a recent 10-year interval. Magnetic Resonance Materials in Physics, Biology and Medicine. 2020 Dec 19;12(12):3839. doi: 10.3390/cancers12123839. The quality of the epidemiological data varies widely between the studies reviewed, however. The Role of miRNA and Related Pathways in Pathophysiology of Uterine Fibroids—From Bench to Bedside. The use of pelvic examination is likely to result in an overestimation of UF incidence as it is not a specific or sensitive test. Feasibility of quantitative MR-perfusion imaging to monitor treatment response after uterine artery embolization (UAE) in symptomatic uterus fibroids. Uterine fibroids are noncancerous growths of the uterus that often appear during childbearing years. Ulipristal acetate for Japanese women with symptomatic uterine fibroids: A double‐blind, randomized, phase II dose‐finding study. Epub 2017 Jun 22. Characteristics associated with prolonged length of stay after myomectomy for uterine fibroids. Uterine fibroids may also have reproductive effects (eg, infertility, adverse pregnancy outcomes). Robot-Assisted Laparoscopic Myomectomy versus Abdominal Myomectomy for Large Myomas Sized over 10 cm or Weighing 250 g. Benign Primary Vaginal Leiomyoma- a diagnostic challenge: Rare case report. 2018. Best Pract Res Clin Obstet Gynaecol. Uterine leiomyomata, commonly called fibroids, are the leading indication for hysterectomy in the United States. Assessing burden, risk factors, and perceived impact of uterine fibroids on women's lives in rural Haiti: implications for advancing a health equity agenda, a mixed methods study. We confined our discussion to 11 important risk factors, by selecting those with a magnitude similar to or greater than the well‐established risk factor of race in at least one study (Table 1). J Obstet Gynaecol Can. Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility. Reproductive status plays a notable role in UF development. 3 Incidence increases with age from menarche to perimenopausal ages. UF risk was up to 70% lower in women who currently used oral contraceptives than in those who had never used them.46, 77, 78 In addition, use of the injectable contraceptive DMPA was found to protect against UF development, more than halving UF risk.77 The mechanism of action of steroidal contraceptives responsible for this effect is not clear. In an Italian single‐centre study, women who currently used oral contraceptives were less than one‐third as likely to have UFs as those who had never used them (Table 1).78 Similar protective effects but of smaller magnitude were reported in the Nurses’ Health Study II, in which UF risk was 20% lower in all current oral contraceptive users and 53% lower in those with a history of 4–5 years’ oral contraceptive use than in women who had never used them,46 and in a multicentre case–control study in Thailand, in which UF risk was 24% lower in all women who had ever used oral contraceptives than in those who had never used them.77 In addition, women who had used the injectable contraceptive depot medroxyprogesterone acetate (DMPA) were less than half as likely to have UFs than those who had never used it (Table 1).77, Women with hypertension, defined as systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg or current use of antihypertensive medication, had an almost fivefold increased risk of UFs compared with those with normal blood pressure in a Japanese single‐centre, case–control study (Table 1).80, In a large case–control survey conducted at a hospital in China, exposure to food additives in processed, sweetened or preserved foods increased the risk of UFs more than threefold compared with no exposure (Table 1).81 The same study found that women who consumed soybean milk had a 2.5‐times greater risk of UFs than those who did not (Table 1).81. Uterine fibroids (UFs) are the most common neoplasm affecting women that can cause significant morbidity and may adversely impact fertility. INTRODUCTION. Steroid hormones and hormone antagonists regulate the neural marker neurotrimin in uterine leiomyoma. Main results: Treatment of patients with uterine myoma in the period of menopausal transition. [ 1, 2] Despite the … The prevalence of UFs varied widely across the studies, from 4.5% to 68.6% (Figure 2).9, 73 Study population characteristics such as country/region and health status (healthy women or those requiring gynaecological care), factors relating to study methodology, including the type of investigation (registry, single‐centre or ‘other observational’ study), and follow‐up time did not consistently influence the prevalence data recorded. Given the hormonal dependence of fibroids, most earlier studies focused on reproductive or hormonal factors. Black race was the only factor that was recurrently reported to increase UF risk, by two-threefold compared with white race. Epidemiology and Risk Factors of Uterine Myomas (Gloria D’Alessandro, MD, Fabio Barra, MD and Simone Ferrero, MD, PhD, Obstetrics and Gynecology, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy, and others) We highlight the advantages of ultrasound screening studies and the ways in which their innovative methods have helped clarify the etiology of disease. Addressing heterogenous outcomes in uterine fibroid research: a call to action. After removal of duplicates, all references were manually screened and categorised. The most common presenting symptom is heavy menstrual bleeding, which can lead to anaemia, and fatigue and painful periods.4-9 Other UF symptoms include non‐cyclic pain, abdominal protuberance, painful intercourse or pelvic pressure, and bladder or bowel dysfunction resulting in urinary incontinence or retention, pain or constipation.4-10 UFs may also be associated with reproductive problems, including impaired fertility, pregnancy complications and loss, and adverse obstetric outcomes.11-18 UFs are one of the leading causes of hospitalisations for gynaecological disorders, and are the most frequent reason for hysterectomy in the USA.19-24, Uterine fibroids are the most common neoplasm affecting women, and it has been postulated that they occur in over 70% of women by the onset of menopause.25-27 They are estimated to be clinically apparent in 25% of women of reproductive age and cause symptoms severe enough in approximately 25% of women with UFs to require treatment.4, 28, 29 The frequency of the condition is, however, likely to be underestimated because in many women it is asymptomatic, or symptoms develop insidiously, and therefore remains undiagnosed.30, 31 The unknown extent and impact of undetected UFs bias the epidemiological data and evidence on associated factors to reflect severe disease.32. MEDLINE and Embase were searched for studies published in English between January 1995 and April 2015. Epub 2020 Sep 19. … The important protective factors were oral or injectable contraceptive use, smoking in women with low BMI and parity. The basic science of uterine fibroids — benign tumors that grow in the uterus and cause an array of health problems — drew researchers from as far away as Spain to a scientific symposium Feb. 28 at NIEHS. BMI, body mass index; CI, confidence interval; DMPA, depot medroxyprogesterone acetate; IRR, incidence rate ratio; OR, odds ratio; RR, relative risk; UFs, uterine fibroids. Women with a positive family history of UFs were over three times more likely to have UFs than those without such a history (Table 1).77, In contrast, smoking, especially in women with low body mass index (BMI), was negatively associated with UF risk. Interstitial Cystitis. Association of Race/Ethnicity with Surgical Route and Perioperative Outcomes of Hysterectomy for Leiomyomas. Vilos GA, Allaire C, Laberge PY, Leyland N; SPECIAL CONTRIBUTORS. Martin CL, Huber LR, Thompson ME, Racine EF. Reduction of myometrial exposure to unopposed estrogen activity by exogenous progestogens may diminish estrogen‐mediated stimulation of UFs.26, 77, 78 This result may, however, represent a selection bias, because UFs and other confounding indications, such as polycystic ovary syndrome, have historically been relative contraindications for steroidal contraceptives.78, 94, Finally, hypertension, food additive and soybean milk consumption were identified to increase UF risk in single‐centre studies.80, 81. Cross-talk between Janus kinase-signal transducer and activator of transcription pathway and transforming growth factor beta pathways and increased collagen1A1 production in uterine leiomyoma cells. Uterine fibroids occur in about 70% of women. Evaluation of the incidence or prevalence of UFs was not the primary objective of most of the included studies, but they were reported in 51 of them. Preface. (A) Incidence of uterine fibroids (UFs) in US registry studies. Journal of Community Hospital Internal Medicine Perspectives. Much of the information available on UF prevalence came from single‐centre studies with populations that were not representative of the general population (e.g. Transverse versus longitudinal uterine incision in abdominal Myomectomy: a systematic review and network meta-analysis are greater. Diverse populations: a systematic review and were gynaecological patients in nearly one third of the data ; and... Herein, we extracted data on UF incidence as it is not a specific or test! Multi-Center database study alternative plasticizers in association with uterine fibroids ( UFs ) are the most common neoplasm affecting that... 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